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PRP Vs. PRF – What’s The Difference?

By Pure Medical Spa

In the world of skin rejuvenation, both Platelet-Rich Fibrin (PRF) and Platelet-Rich Plasma (PRP) are innovative solutions for a variety of anti-aging treatments. While both are derived from a patient’s blood and contain high concentrations of platelets and growth factors, they do differ. Today at PURE Medical Spa, we are exploring PRP vs. PRF to determine what’s the difference between the two and how they are used in aesthetic treatments.

PRP and PRF have versatile applications in a variety of treatments like facial rejuvenation, hair restoration and acne scar treatment. The choice between PRP and PRF depends on factors like the concern being addressed, desired results and provider recommendations.


What Is PRF?

Platelet-Rich Fibrin (PRF) is a therapeutic substance derived from a patient’s own blood. It is prepared by centrifuging a blood sample to separate out platelets and fibrin, which are then combined to form a fibrin clot rich in platelets and growth factors. PRF is used in various medical and dental procedures to promote tissue healing and regeneration.

At PURE, we use PRF in skin rejuvenation and hair loss treatments. By injecting it into the skin, we can stimulate collagen production for improved skin texture, easing the appearance of fine lines and wrinkles. Additionally, PRF injections can be used to promote hair growth and improve the thickness and quality of hair in individuals experiencing hair loss or thinning.


What Is PRP?

Platelet-Rich Plasma (PRP) is a substance derived from a patient’s own blood. It is prepared by taking a small sample of blood and then centrifuging it to separate the platelet-rich plasma from other blood components.

One of the main differences between PRP vs PRF is PRP contains a higher concentration of platelets than normal blood, along with various growth factors and cytokines that play essential roles in tissue repair and regeneration. These growth factors include platelet-derived growth factor, transforming growth factor beta, vascular endothelial growth factor and others.


Why Does PRF Work Better For Some Treatments Over PRP

PRF may work better for some treatments over PRP due to several factors:

  • PRF contains a fibrin matrix that provides structural support and acts as a scaffold for tissue regeneration, potentially enhancing its effectiveness in certain applications.
  • PRF releases growth factors gradually over time, promoting prolonged tissue healing and regeneration compared to the more rapid release of growth factors with PRP.
  • PRF contains a higher concentration of leukocytes, which play a role in immune response and tissue repair, potentially contributing to enhanced healing and better treatment outcomes in specific cases.
  • The fibrin matrix and gradual release of growth factors in PRF may result in longer-lasting effects compared to PRP, making it preferable for treatments requiring sustained tissue regeneration.


Aesthetic Procedures Using PRP

PRP and PRF are both utilized in various aesthetic procedures and treatments for their regenerative properties but due to subtle differences between the two, here’s how PRP is commonly used:

Facial Rejuvenation

PRP injections can be used for facial rejuvenation to improve skin texture, reduce fine lines and wrinkles, and enhance overall skin tone and radiance.

Hair Restoration

PRP injections are commonly employed in the treatment of hair loss, particularly in conditions like androgenic alopecia (male and female pattern baldness). PRP can stimulate hair follicles, promote hair growth, and improve hair thickness and density.

Acne Scars

PRP injections can be combined with other procedures like microneedling to improve the appearance of acne scars by promoting collagen production and tissue regeneration.

Healing Properties

PRP may be used to accelerate the healing process and improve outcomes in procedures like laser treatments, chemical peels, and dermal filler injections.


Treatments Incorporating PRF

When it comes to PRP vs PRF, there are a variety of anti-aging treatments where the use of PRF may provide more lasting results:

Skin Appearance

PRF can be used similarly to PRP for facial rejuvenation procedures to improve skin quality, reduce wrinkles, and enhance overall skin appearance. The fibrin matrix in PRF may provide longer-lasting effects compared to PRP.

Tissue Regeneration

PRF can be combined with hyaluronic acid dermal fillers to enhance their effectiveness and promote tissue regeneration, resulting in improved volume restoration and longer-lasting results.

Wound Healing

PRF is utilized in various medical and aesthetic procedures to accelerate wound healing and tissue regeneration, particularly in cases of chronic wounds or difficult-to-heal wounds.

Orthopedic Injuries

PRF is also used in orthopedic medicine for the treatment of musculoskeletal injuries, like tendon and ligament injuries, osteoarthritis, and other degenerative joint conditions, to promote tissue repair and reduce inflammation.



What Distinguishes PRF from PRP?

PRF contains a higher concentration of fibrin and leukocytes compared to PRP, making it thicker and potentially more effective for tissue regeneration. PRF is predominantly used in fields like dentistry, oral surgery, dermatology and orthopedics.

Does PRF Work For Men And Women?

Yes, studies have shown that PRF is an effective treatment for hair loss in both men and women. It has also been used to treat alopecia, a condition that causes baldness. Not only does PRF help restore lost hair, but it can also improve the quality of the hair that remains.

What Are The Notable Advantages Of Choosing PRF vs. PRP?

PRF is generally considered safe and effective when performed by a qualified healthcare professional. Notable advantages of PRF over PRP include its potential for longer-lasting effects, sustained release of growth factors, and higher concentration of leukocytes for enhanced tissue healing.

How Long Does It Take To See Results With PRF?

Results with PRF may vary depending on the specific treatment and individual factors, but improvements are often noticeable within a few weeks to months. However, multiple sessions may be needed to achieve optimal results, especially for aesthetic procedures like hair restoration.


Why Choose PURE Medical Spa For These Treatments

From the moment you step into PURE Medical Spa, we provide an exclusive aesthetic experience customized for your needs. Through high-quality treatments including PRP and PRF for skin rejuvenation or hair growth, we are passionate about top-notch technology and a staff trained by the best of the best.

We offer in-person consultations and virtual consultations for your convenience. Plus, our PURE app gives you everything you need at your fingertips. Start your aesthetic journey today by booking a consultation and experience the luxury and expertise that awaits at PURE.